Importância histórica, química e farmacológica dos alucinógenos naturais alcaloidais
DOI:
https://doi.org/10.47236/2594-7036.2021.v5.i4.56-67pKeywords:
Alucinógenos. Produtos Naturais. Alcaloides. Química. Farmacologia.Abstract
Produtos naturais alucinógenos constituem um importante e interessante grupo de substâncias, em especial os alcaloides, classe de substâncias para as quais são observadas inúmeras atividades biológicas e farmacológicas, incluindo as propriedades alucinógenas apresentadas por várias espécies vegetais que contêm tais metabólitos. Reconhecendo-se a importância histórica, química e farmacológica dos alucinógenos alcaloidais, este estudo teve por objetivo abordar e discutir, com base na literatura específica, aspectos relevantes sobre a história, a química e a farmacologia de alucinógenos naturais alcaloidais clássicos, como: DMT, escopolamina, harmina, hiosciamina, ibogaína, LSA, mescalina, psilocibina e psilocina.Downloads
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ABRAHAM, H. D.; ALDRIDGE, A. M.; GOGIA, P. The psychopharmacology of hallucinogens. Neuropsychopharmacology, v. 14, n. 4, p. 285-298, 1996.
AGHAJANIAN, G. K.; MAREK, G. J. Serotonin and hallucinogens. Neuropsychopharmacology, v. 21, n. 2, p. 16-23, 1999.
ALPER, K.; REITH, M. E. A.; SERSHEN, H. Ibogaine and the inhibition of acetylcholinesterase. Journal of Ethnopharmacology, v. 139, n. 1, p. 879-882, 2012.
BAHAR, M. et al. Plant-derived natural products in drug discovery and development: an overview. In: IKAN, R. (Org.). Selected topics in the chemistry of natural products. Singapore: World Scientific Publishing Co, 2008.
BRIELMANN, H. R. et al. Phytochemicals: the chemical components of plants. In: BRIELMANN, H. R. et al. Natural Products from Plants. Boca Raton: CRC Press, 2006.
BRIERLEY, D. I.; DAVIDSON, C. Developments in harmine pharmacology – implications for ayahuasca use and drug-dependence treatment. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 39, n. 1, p. 263-272, 2012.
CARAI, M. A. M. et al. Potential use of medicinal plants in the treatment of alcoholism. Fitoterapia, v. 71, n. 1, p. 38-42, 2000.
CARLINI, E. A. Plants and the Central Nervous System. Pharmacology, Biochemistry and Behavior, v. 75, n. 1, p. 501-512, 2003.
CODY, J. T. Hallucinogens. Forensic Science, v. 2, n. 13, p. 143-162, 2000.
CREWS, C. Analysis of ergot alkaloids. Toxins, v. 7, n. 1, p. 2024-2050, 2015.
DEWICK, P. M. Medicinal natural products: a biosynthetic approach. 2. ed. Chichester: John Wiley & Sons, 2002.
EL-SEEDI, H. R. et al. Prehistoric peyote use: alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas. Journal of Ethnopharmacology, v. 101, n. 3, p. 238-242, 2005.
FARIA, K. G. O.; ALMEIDA, V. A. F. O.; FRANÇA, R. F. Alucinógenos: toxicologia e bases fisiológicas. Revista Saúde em Foco, v. 13, n. 1, p. 127-141, 2021.
FREEDLAND, C. S.; MANSBACH, R. S. Behavioral profile of constituents in ayahuasca, an Amazonian psychoactive plant mixture. Drug and Alcohol Dependence, v. 54, n. 1, p. 183-194, 1999.
GOULART, S. L. A política das religiões ayahuasqueiras brasileiras: droga, religião e direitos. Religião & Sociedade, v. 39, n. 2, p. 200-221, 2019.
HALPERN, B. L. Hallucinogens and dissociative agents naturally growing in the United States. Pharmacology & Therapeutics, v. 102, n. 1, p. 131-138, 2004.
KOHNEN-JOHANNSEN, K. L.; KAYSER, O. Tropane alkaloids: chemistry, pharmacology, biosynthesis, and production. Molecules, v. 24, n. 1, p. 796-819, 2019.
KOLEVA, I. et al. Alkaloids in the human food chain – natural occurrence and possible adverse effects. Molecular Nutrition & Food Research, v. 56, n. 1, p. 30-52, 2012.
MARTINEZ, S. T.; ALMEIDA, M. R.; PINTO, A. C. Alucinógenos naturais: um voo da Europa medieval ao Brasil. Química Nova, v. 32, n. 9, p. 2501-2507, 2009.
MATSUURA, H.; FETT-NETO, A. Plant Alkaloids: Main Features, Toxicity, and Mechanisms of Action. In: GOPALAKRISHNAKONE, P. et al. Plant Toxins. Dordrecht: Springer, 2015.
MCKENNA, D. J. Plant hallucinogens: springboards for psychotherapeutic drug discovery. Behavioural Brain Research, v. 73, n. 1, p. 109-115, 1996.
MCKENNA, D. J.; CALLAWAY, J. C.; GROB, C. S. The scientific investigation of ayahuasca: a review of past and current research. The Heffter Review of Psychedelic Research, v. 1, n. 1, p. 65-76, 1998.
NICHOLS, D. E. Hallucinogens. Pharmacology & Therapeutics, v. 101, n. 1, 131-181, 2004.
OTT, J. Pharmahuasca: human pharmacology of oral DMT plus harmine. Journal of Psychoactive Drugs, v. 31, n. 1, p.171-177, 1999.
PATEL, K. et al. A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine”. Asian Pacific Journal of Tropical Medicine, v. 2, n. 8, p. 660-664, 2012.
RICHARDSON, W. H.; SLONE, C. M.; MICHELS, J. E. Herbal drugs of abuse: an emerging problem. Emergency Medicine Clinics of North America, v. 25, n. 2, p. 435-457, 2007.
SANTOS, R. G. dos. Ayahuasca: neuroquímica e farmacologia. Revista Eletrônica Saúde Mental, Álcool e Drogas, v. 3, n. 1, 2007.
SANTOS, A. E.; DUARTE, A.; FERREIRA, W. J. Produtos naturais alucinógenos: aspectos históricos, químicos e farmacológicos. Conecta Fasf, v. 3, n. 1, 2018.
SCHULTES, R. E. Hallucinogenic plants: a golden guide. New York: Golden Press, 1976.
SCHULTES, R. E. The botanical and chemical distribution of hallucinogens. Journal of Psychedelic Drugs, v. 9, n. 3, p. 247-263, 1977.
SCHULTES, R. E., HOFMANN, A., RATSCH, C. Plants of the Gods: their sacred, healing and hallucinogenic powers. Rochester: Healing Arts Press, 1992.
SCHULTES, R. E. Antiquity of the use of new world hallucinogens. The Heffter Review of Psychedelic Research, v. 1, n. 1, p. 1-7, 1998.
SONI, P. et al. Pharmacological properties of Datura stramonium as a potential medicinal tree: an overview. Asian Pacific Journal of Tropical Biomedicine, v. 2, n. 12, p. 1002-1008, 2012.
VIEGAS-JUNIOR, C. et al. Aspectos químicos, biológicos e etnofarmacológicos do gênero Cassia. Química Nova, v. 29, n. 6, p. 1279-1286, 2006.
WEIL, A. T.; DAVIS, W. Bufo alvaris: a potent hallucinogen of animal origin. Journal of Ethnopharmacology, v. 41, n. 2, p. 1-8, 1994.
WOLBACH, A. B.; MINER, E. J.; ISBELL, H. Comparison of psilocin with psilocybin, mescaline and LSD. Psychopharmacologia, v. 3, n. 1, p. 219-223, 1962.
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