Effects of mulberry (Morus spp.) on the management of menopausal symptoms: An integrative review
DOI:
https://doi.org/10.47236/2594-7036.2025.v9.1687Keywords:
Phytoestrogens, Menopause, Morus sppAbstract
Menopause is a transitional phase in a women's life, characterized by a reduction in estrogen and progesterone production, which triggers symptoms such as hot flashes, night sweats, insomnia, irritability, and metabolic changes, affecting quality of life. Due to the adverse effects of Hormone Replacement Therapy (HRT), interest in natural alternatives has increased, such as mulberry (Morus spp.), which is rich in phytoestrogens and antioxidant compounds that may assist in hormonal regulation and protection against oxidative stress. This study aimed to analyze the efficacy of mulberry as a therapeutic alternative for relieving menopausal symptoms through an integrative literature review. The databases Periódicos Capes, PubMed, Google Scholar, and Virtual Health Library (VHL) were consulted, including studies published between 2019 and 2024 on the effects of Morus nigra and Morus alba, as well as research on bioavailability, safety, and innovative formulations. The results highlight that Morus species contain flavonoids, anthocyanins, and alkaloids with antioxidant, anti-inflammatory, and phytoestrogenic activities. Regular consumption of the plant, in the form of teas, capsules, or formulations such as gummies and mucoadhesive films, has shown benefits in reducing symptoms like hot flashes, insomnia, and mood swings. Additionally, mulberry exhibits antiglycation activity, which may help prevent metabolic complications associated with aging. Despite the promising results, the literature still lacks controlled clinical trials and standardized dosages, making it necessary to conduct more robust research to consolidate the use of Morus spp. in clinical practice.Downloads
Metrics
References
BRÁS, Naomi Matsura Fisiopatologia da menopausa e manejo terapêutico dos sintomas associados. 2023. 43f. Monografia (Trabalho de conclusão de curso) – Universidade Federal de São Paulo (UNIFESP), 2023.
BURTIS, Carl A. et al. Fundamentos de Química Clínica. 6. ed. Rio de Janeiro: Elsevier, 2008.
COSTA, Joyce P. L. et al. Randomized double-blind placebo-controlled trial of the effect of Morus nigra L. (black mulberry) leaf powder on symptoms and quality of life among climacteric women. International Journal of Gynecology & Obstetrics, v. 148, n. 2, p. 243-252, 2020. DOI: https://doi.org/10.1002/ijgo.13057
DA SILVA, Ingrid Möller et al. A percepção das mulheres a respeito dos sinais e sintomas do climatério/menopausa e sua relação com a qualidade de vida. Pesquisa, Sociedade e Desenvolvimento, v. 4, pág. e38811427374, 2022. DOI: https://doi.org/10.33448/rsd-v11i4.27374
DO CARMO, Isabella Abidalla et al. Indicações e contraindicações do uso de terapia de reposição hormonal. Brazilian Journal of Health Review, v. 6, n. 5, p. 24279-24286, 2023. DOI: https://doi.org/10.34119/bjhrv6n5-478
FERREIRA, Isabella Ferraz et al. Impactos do tratamento hormonal e não hormonal sobre a sintomatologia vasomotora de mulheres climatéricas. Revista Eletrônica Acervo Científico, v. 16, p. e5614, 2020. DOI: https://doi.org/10.25248/reac.e5614.2020
GOMES, Amanda C. et al. Antiglycation and antioxidant activity of herbal medicines used in the treatment of climacteric symptoms. Journal of Herbal Medicine, v. 41, p. 100689, 2023. DOI: https://doi.org/10.1016/j.hermed.2023.100689
LINS, Letícia Marques Rodrigues et al. Impactos da menopausa na saúde da mulher. Revista Brasileira de Revisão de Saúde, v. 5, pág. 12018-12031, 2020. DOI: https://doi.org/10.34119/bjhrv3n5-053
MACHADO, Larissa Nunes. ALANO, G. M. DO NASCIMENTO, D. Z. Climatério e Terapia de Reposição Hormonal por mulheres em um município do Sul de Santa Catarina. Revista da Associação Médica do Rio Grande do Sul, p. 01022105-01022105, 2021.
MIRANDA, Sandrine da Silva et al. O chá da folha de Morus nigra como agente promotor de qualidade de vida em mulheres na transição menopáusica. Revista Eletrônica Acervo Saúde, v. 9, pág. e4288, 2020. DOI: https://doi.org/10.25248/reas.e4288.2020
MOREIRA, Ana C et al. Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown. Journal of Steroid Biochemistry and Molecular Biology, v. 61-71, 2014. DOI: https://doi.org/10.1016/j.jsbmb.2014.01.016
NASCIMENTO, Geovana Braz et al. Reposição hormonal e risco cardiovascular na menopausa: uma revisão bibliográfica. Revista Brasileira de Revisão de Saúde, v. 1, pág. 4692-4706, 2024. DOI: https://doi.org/10.34119/bjhrv7n1-379
OLIVEIRA, Lilian Elizama de Abreu et al. Menopause and behavioral effects: How to proceed? Literature review. Pesquisa, Sociedade e Desenvolvimento, v. 1, pág. e12112139479, 2023.
RODRIGUES, Isabela Alves et al. Formulação e avaliação de goma, a partir do extrato de amora preta, como alternativa no tratamento dos sintomas da menopausa. Revista Multidisciplinar da Saúde, v. 3, pág. 141-165, 2022.
RODRIGUES, Sidney de Oliveira et al. A fitoterapia Morus nigra: como alternativa no tratamento dos sintomas da menopausa. Revista Brasileira de Desenvolvimento, v. 7, n. 4, pág. 38529-38542, 2021. DOI: https://doi.org/10.34117/bjdv7n4-354
SALES, Aline Pereira de Andrade. O uso da fitoterapia como atenuante dos sintomas do climatério. 2021. Monografia (Especialização em Residência Multiprofissional em Práticas Integrativas) – Secretaria Municipal da Saúde de São Paulo, São Paulo, 2021.
SANTOS, Joyce Silva dos; ALMEIDA, C.C.O.F (orgs.). Das Plantas Medicinais à Fitoterapia: uma ciência em expansão. Brasília: Editora IFB, 2016.
SANTOS, Maria Carolina Fernandes Dos. Desenvolvimento e caracterização de filme mucoadesivo bucal contendo extrato de Morus nigra L. para tratamento de sintomas climatéricos. 2023. Monografia (Bacharel em Biomedicina) – Universidade Federal da Paraíba, João Pessoa, 2023.
SILVA, Mariane Daniella. SILVEIRA, M. A. ERNANDES, F. M. Uso dos fitoterápicos isoflavona e folhas de amora como tratamento no climatério: revisão sistemática. Concilium, v. 22, n. 6, pág. 107-116, 2022. DOI: https://doi.org/10.53660/CLM-525-613
TRICCO, Andrea C. et al. Extensão PRISMA para revisões de escopo (PRISMA-ScR): lista de verificação e explicação. Annals of Internal Medicine, v. 169, n. 7, p. 467–473, 2018. DOI: https://doi.org/10.7326/M18-0850
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Renatta Cardoso da Silva, Lunalva Aurélio Pedroso Sallet, Kátia Paulino de Sousa
This work is licensed under a Creative Commons Attribution 4.0 International License.
It allows sharing, adaptation, and use for any purpose, including commercial use, provided proper attribution is given to the authors and to Revista Sítio Novo.
The authors declare that the work is original and has not been previously published, in whole or in part, except on recognized preprint servers, if declared, and that no other similar manuscript authored by them is published or under review by another journal, whether printed or electronic.
They declare that they have not violated or infringed upon any proprietary rights of others, and that all citations in the text are factual or based on research with scientifically significant accuracy.
The authors retain the copyright of the manuscripts published in this journal, allowing unrestricted use of their content, provided that the original authorship and the publication source are properly cited.
